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Immune responses after live attenuated influenza vaccination

Two types of influenza vaccine are widely available: inactivated influenza vaccines (IIV) and live attenuated influenza vaccines (LAIV). Traditionally, influenza vaccines (both IIV and LAIV) have been produced to protect against 3 different seasonal influenza viruses (also called trivalent vaccines). In most countries this is still the case and ...

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Intranasal powder live attenuated influenza vaccine is ... - Nature

Summary of Data Reviewed. Review of LAIV effectiveness data for previous seasons in the United States confirms low to no significant effectiveness of LAIV against influenza A (H1N1)pdm09-like viruses. However, LAIV was generally effective against influenza B viruses and was of similar effectiveness to IIV against influenza A (H3N2) viruses.

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This is the first study to evaluate the safety and viral shedding of LAIV in Chinese healthy juveniles and adults. LAIV has many advantages. LAIV imitates natural infection, stimulating mucosal and humoral immunity without causing severe illness. LAIV was produced by growing attenuated influenza viruses in chick embryo cells . These attenuated ...

Influenza Vaccine - Influenza Vaccine - Merck ... - The Merck Manuals

LAIV efficacy and its impact on vulnerable groups are still debated. This systematic review aims to investigate whether the LAIV is safe and effective in adults, including those with underlying clinical conditions, pregnant women, and children younger than 24 months.